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Tumorigenicity of EBV‐carrying lymphoblastoid cell lines (LCLS): Distinctive grading in scid mice
Author(s) -
Ramqvist Torbjörn,
Norén Lennart,
Iwarsson Krister,
Klein George
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910490420
Subject(s) - in vivo , in vitro , lymphoblast , grading (engineering) , cell culture , biology , cancer research , epstein–barr virus , cell growth , immunology , pathology , virology , virus , medicine , genetics , ecology
The in vitro and in vivo growth of lymphoblastoid cell lines (LCLs), Burkitt lymphomas (BLs) and PBL‐derived immunoblastomas in SCID mice was studied in parallel. Most, but not all, of the LCLs tested were tumorigenic in SCID mice. Long‐term culturing in vitro was not a necessary prerequisite for tumorigenicity. There was a good correlation between in vivo and in vitro growth. Three major classes of cells could be distinguished on the basis of their growth properties.