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Anti‐tumoral activity of L and D isomers of aspartic acid β‐hydroxamate on L5178Y leukemia
Author(s) -
Thomasset Nicole,
HamediSangsari Farid,
Tournaire Roselyne,
Navarro Claudine,
Malley Serge,
Goetsch Liliane,
Grange Jacques,
Vila Jorge
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910490319
Subject(s) - in vivo , aspartic acid , leukemia , in vitro , asparagine , chemistry , stereochemistry , biochemistry , immunology , biology , amino acid , genetics
D and L isomers of aspartic acid β‐hydroxamate (respectively DAH and LAH) were compared for their in vitro and in vivo activity against the murine leukemia L5178Y and their tolerance in vivo in DBA/2 mice. DAH and LAH displayed comparable cytotoxic activity against L5178Y leukemia in vitro . Death of leukemia cells was observed at concentrations above 1.2 mM for both DAH and LAH. High concentrations of L‐asparagine partially reversed the growth‐inhibitory effects of DAH and LAH on L5178Y cells for concentrations of DAH and LAH lower than 0.6 mM. Intraperitoneal administration of DAH and LAH to mice showed that the LD 10 , LD 50 and LD 90 of DAH was 3‐ to 4‐fold greater for DAH than for LAH. DAH was able to eradicate L5178Y tumors in mice without inducing toxic deaths, whereas LAH at comparable doses killed all the animals treated.