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Association of ki‐ ras mutation with differentiation and tumor‐formation pathways in colorectal carcinoma
Author(s) -
LaurentPuig P.,
Olschwang S.,
Delattre O.,
Validire P.,
Melot T.,
Mosseri V.,
Salmon R. J.,
Thomas G.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910490213
Subject(s) - point mutation , mutation , pathology , carcinoma , colorectal cancer , adenoma , biology , mutation frequency , mucinous carcinoma , epithelioma , oncogene , cancer research , adenocarcinoma , cellular differentiation , cancer , medicine , gene , genetics , cell cycle
The occurrence of a point mutation on the 12th and 13th codons of the Ki‐ ras oncogene has been investigated in 99 colorectal carcinomas in relation to 3 histological parameters: extent of differentiation, occurrence of a mucinous component within the tumor, and presence of peripheral adenomatous polyp remnants. The mutation frequency increased with each parameter: from 13% (2/15) to 44% (37/84) with differentiation, from 33% (26/79) to 65% 13/20) with mucinous character, and from 27% (15/56) to 56% (24/43) with the presence of polyp remnants. The frequency was highest in well‐differentiated mucinous tumors with adenomatous remnants 83% (5/6). We suggest that Ki‐ ras mutation is preferentially involved in carcinomas that have developed from adenoma and that the mutation preserves differentiation and much secretion in these cancer cells.