Premium
Depot‐medroxyprogesterone acetate (DMPA) and risk of liver cancer
Author(s) -
Mati J. G.,
Kenya P.,
Kungu A.,
Gatei D.,
Silpisoronkosol Suporn,
Pardthaisong Tieng,
Sahapong Virote,
Theetrat Choti,
Boosiri Banpot,
Chutivongse Supawat,
Virutmasen Pramuan,
Wongsrchanalai Chansuda,
Sindhvananda Sermsri,
Koetsawang Suporn,
Rachawat Daungdao,
Koetsawang Amom,
Anthony P. P.,
Thomas David B.,
Noonan Elizabeth A.,
Ray Roberta M.,
Rosenblatt Karin A.,
Stanford Janet L.,
Holck Susan,
Farley Timothy M. M.,
Rosenblatt Karin A.,
Thomas David B.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910490206
Subject(s) - medroxyprogesterone acetate , medicine , liver cancer , gynecology , medroxyprogesterone , hepatocellular carcinoma , cancer , confounding , relative risk , population , hepatitis , family planning , obstetrics , environmental health , research methodology , estrogen , confidence interval
Abstract A hospital‐based case‐control study was conducted to assess the possible relationship between use of depot‐medroxy‐progesterone acetate (DMPA), an injectable progestational contraceptive, and the development of liver cancer in 2 developing countries where hepatitis B is endemic. Information about prior DMPA use and potential confounders was ascertained during personal interviews with 71 cases and 530 controls from 3 hospitals in Thailand and 1 hospital in Kenya. No significant association between liver cancer and DMPA use was observed in Kenya (RR = 1.64, 95% CI = 0.4‐0.6) or Thailand (RR = 0.33, 95% CI = 0.1‐1.O). No consistent changes in risk were observed with duration of use, time since last use, or time since first use. No significant associations were observed between DMPA use and risks of either hepatocellular carcinoma or cholangiocarcinoma. These findings suggest that risk of liver cancer in areas where hepatitis B is endemic is not appreciably altered by the use of DMPA.