Premium
Trisomy 12 and K‐ ras ‐2 Amplification in human ovarian tumors
Author(s) -
YangFeng Teresa L.,
Li ShiBo,
Leung WahYing,
Carcangiu Maria L.,
Schwartz Peter E.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910480508
Subject(s) - trisomy , chromosomal abnormality , biology , pathology , gene duplication , cytogenetics , aneuploidy , karyotype , chromosome , cancer research , medicine , genetics , gene
Cytogenetic analysis was performed on 11 benign and borderline ovarian tumors. Trisomy 12, identified as a sole abnormality in 6 tumors, is likely a specific karyotypic change in different benign and borderline tumors and may well be a primary chromosomal lesion in these tumors. The possible association between amplification of the proto‐oncogene K‐ ras ‐2 which Is located on chromosome 12 and trisomy 12 was Investigated. DNA blotting analysis of 64 tumors indicates that trisomy 12 does not seem to be related to K‐ ras ‐2 amplification in ovarian tumors. K‐ ras ‐2 amplification was observed in 3 high‐grade tumors from 3 patients with metastases.