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Selective homing of phenotypically lytic cells within nasopharyngeal carcinoma biopsies: Numerous CD8‐ and CD16‐positive cells in the tumor
Author(s) -
Lakhdar M.,
Aribia M. H. Ben,
Maalej M.,
Ladgham A.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910480111
Subject(s) - nasopharyngeal carcinoma , homing (biology) , lytic cycle , biology , cd8 , monoclonal antibody , immunology , concanavalin a , cytotoxic t cell , cd16 , tumor infiltrating lymphocytes , cancer research , microbiology and biotechnology , immune system , antibody , cd3 , medicine , in vitro , virus , radiation therapy , ecology , biochemistry
Abstract We present a comparative analysis of cell‐mediated immunity between circulating lymphocytes and tumor‐infiltrating lymphocytes (TIL) from patients with nasopharyngeal carcinoma (NPC). Phenotypic analysis using a panel of monoclonal antibodies (MAbs) to define lymphocytic subsets has revealed a selective homing of phenotypically lytic cells such as CD8‐and CD 16‐positive cells, but a low percentage of macrophages when compared to PBL of NPC patients. Also, PBL and TIL contain an equivalent percentage of activated T‐lymphocytes expressing HLA‐DR molecules and IL‐2 receptors. Functionally, TIL exhibit an abolished NK‐cell activity and concomitant decrease of proliferative response to phytohemaglutinin (PHA) and concanavalin A (ConA) stimulation when compared with PBL.