Premium
The role of fat, animal protein and some vitamin consumption in breast cancer: A case control study in Southern France
Author(s) -
Gerber Mariette,
Cenée Sylvie
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910480102
Subject(s) - animal fat , odds ratio , medicine , fat soluble vitamin , vitamin , animal food , saturated fat , retinol , nutrient , multivariate analysis , food science , breast cancer , vitamin e , case control study , animal studies , physiology , environmental health , cancer , biology , cholesterol , biochemistry , ecology , antioxidant
The role of the consumption of fat, animal protein and vitamins on breast‐cancer risk was investigated in a hospital‐based case‐control study of 924 patients (409 cases and 515 controls) in Montpellier (France). A dietary history questionnaire, administered by interview, comprising 55 key food items as well as beverage consumption, and including food frequencies and portion sizes, was used to measure the intake of total fat and its constituents, animal protein, retinol, β‐carotene, vitamin E and alcohol consumption. The questionnaire also elicited information on relevant medical history and personal characteristics. All food items which showed significantly elevated odds ratio (high‐fat cheese, desserts and chocolate and processed pork meat) in a multivariate analysis contained a high proportion of animal fat. This is reflected in the nutrient analysis, which showed a significant linear trend as well as an elevated odds ratio for the highest fertile of consumption of total fat [OR 3 = 1.6 (1.1–2.2)], animal fat [OR 3 = 1.6 (1.1–2.2)], saturated fat [OR 3 = 1.9 (1.3–2.6)] and mono‐unsaturated fat [OR 3 = 1.7 (1.2–2.5)]. For post‐menopausal women, there is a particularly strong association with saturated fat [OR 3 = 3.3 (1.4–7.8)] in a multivariate analysis including all other significant nutrients. There is no evidence of an increase of risk with the intake of animal protein and no evidence of risk reduction with increased consumption of vegetables, β‐carotene or vitamin E. Along with some recent studies, our results give support to the hypothesis that dietary fat is a risk factor in breast carcinogenesis.