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T‐cell subset analysis of 3LL tumor growth
Author(s) -
Gelber Cohava,
Eisenbach Lea,
Feldman Michael,
Goodenow Robert S.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470715
Subject(s) - cytotoxic t cell , in vivo , cd8 , monoclonal antibody , lewis lung carcinoma , biology , cancer research , effector , t cell , t cell receptor , metastasis , cell growth , in vitro , immunology , antibody , cancer , antigen , immune system , genetics
We have partially characterized the T‐cell subsets that control the growth of the C57BL/6 Lewis lung carcinoma 3LL transplanted into syngeneic mice. By analyzing the phenotypes of anti‐tumor lymphocytes generated in vitro and in vivo , we have characterized a CD8 T‐cell receptor (TcR) Vβ 5,6 positive subpopulation of cytotoxic effectors important in retarding the growth of the transplanted tumor. In contrast, the rejection of 3LL appears to be hindered by the presence of a CD4 Vβ 11‐positive subset since depletion of these lymphocytes in vivo with the appropriate monoclonal antibodies (MAbs) results in significant retardation of tumor growth. These results suggest that the cumulative positive and negative effects of distinct T‐cell sub‐populations determine the outcome of tumor progression and metastasis.