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The HLA‐DRB6 locus defines an evolutionary supratypic group within the DRB family of genes
Author(s) -
Corell A.,
MartinVilla J. M.,
Morales P.,
de Juan M. D.,
Vicario J. L.,
MartínezLaso J.,
Varela P.,
ArnaizVillena A.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470708
Subject(s) - locus (genetics) , genetics , human leukocyte antigen , gene , biology , antigen
A novel DRB gene member has recently been identified (DRB6). It defines a new supratypic group of HLA‐DR alleles comprising the DR1‐, DR2‐, and DRw 10‐carrying haplotypes. The comparison of this gene either at the nucleotide or at the protein level with other HLA‐DRB genes supports its inclusion in the DRB gene family and not in DPB or DQB gene families. Moreover, the construction of an evolutionary gene‐tree shows that this gene is probably the eldest member of the DRB gene family. Contradictory expression results do not clarify whether or not DRB6 is a pseudogene.