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Peptide‐mediated allo‐recognition of HLA‐B27 by cytotoxic T lymphocytes
Author(s) -
Rojo Susana,
de Castro José A. López
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470704
Subject(s) - ctl* , cytotoxic t cell , human leukocyte antigen , biology , antigen , hla b27 , immunology , endogeny , cd8 , genetics , biochemistry , in vitro
The molecular basis of the recognition of class‐1 HLA antigens by allo‐reactive cytotoxic T lymphocytes (CTL) remains obscure. This article reviews our work in which HLA‐B27‐specific allo‐reactive CTL clones were obtained and their fine specificity was analyzed with a panel of structurally defined HLA‐B27 natural variants and site‐directed mutants expressed on human and mouse cells. The results have implications for the involvement of endogenous peptides in determining the clonal diversity of HLA‐B27 allogeneic responses and the fine specificity of T‐cell recognition when HLA‐B27 is expressed on different cell types.