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Comparative analysis of the expression of the extracellular matrix protein tenascin in normal human fetal, adult and tumor tissues
Author(s) -
Natali Pier Giorgio,
Nicotra Maria Rita,
Bigotti Aldo,
Botti Claudio,
Castellani Patrizia,
Risso Anna Maria,
Zardi Luciano
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470603
Subject(s) - tenascin , extracellular matrix , immunohistochemistry , pathology , tenascin c , biology , stroma , fetus , glycoprotein , stromal cell , embryonic stem cell , monoclonal antibody , microbiology and biotechnology , cancer research , antibody , fibronectin , immunology , medicine , pregnancy , gene , genetics
Tenascin (TN) is a high‐molecular‐mass oligomeric glycoprotein of the extracellular matrix (ECM) endowed with a programmed expression in embryonic life and a neo‐expression in the interstitium of some malignancies. Using monoclonal antibodies (MAbs) which identify human tenascin, we have conducted an extensive immunohistochemical analysis of TN expression in normal fetal and adult human tissues as well as in a wide variety of human tumors. Results of this study demonstrate that TN (1) is detectable in embryonic and fetal tissues at least from the 10th week of gestation; (2) is present in the interstitium of a variety of adult tissues of different embryonic origin; (3) may be neo‐expressed in the stroma of benign and malignant tumors; (4) has the ability to accumulate in a highly variable manner in the ECM of tumors of the same and of different histotypes.