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Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients
Author(s) -
Anttila Sisko,
Hietanen Eino,
Vainio Hard,
Camus AnneMarie,
Gelboin Harry V.,
Park Sang S.,
Heikkilä Lasse,
Karjalainen Antti,
Bartsch Helmut
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470509
Subject(s) - lung cancer , lung , pathology , cancer , adenocarcinoma , carcinogen , peripheral , immunohistochemistry , medicine , cytochrome c , biology , apoptosis , biochemistry
A specific member of the cytochrome P450 super‐family of enzymes, designated P450IA (including 2 isozymes, P450IAI and P450IA2), which is involved in the metabolic activation of polycyciic aromatic hydrocarbons and aromatic amines, was studied in lung tissue from 25 lung cancer patients by immunohistochemistry. The pulmonary activity of a P450IAI‐dependent enzyme, aryl hydrocarbon hydroxylase (AHH), from the same patients was also measured. Cytochrome P4S0IA was localized principally in the peripheral airways in alveolar epithelium of types I and II and in ciliated columnar and cuboidal bronchiolar epithelium. The amount of P450IA in the bronchial wall was minimal and was localized mainly in the capillary endothelium and the epithelium of the bronchial glands. Smoking was the most important factor related to the presence of P450IA and the AHH activity in lung tissue. None of the 10 ex‐smokers, but all except I of the current smokers had detectable levels of P450IA. The localization of the cancer was also correlated with the presence of cytochrome P450IA. Peripheral lung tissue stained positively in all patients with a peripheral adenocarcinoma who currently smoked (8/8) but in less than half of those with a bronchial cancer who were smokers (3/7). Our data suggest that the smokers who have an inducible cytochrome P450IA are especially at increased risk of developing lung cancer of the peripheral adenocarcinomatous type.