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Inhibition of respiration of tumor cells by methylglyoxal and protection of inhibition by lactaldehyde
Author(s) -
Ray Manju,
Halder Jyotsnabaran,
Dutta Samir K.,
Ray Subhankar
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470421
Subject(s) - methylglyoxal , respiration , ascorbic acid , biochemistry , ehrlich ascites carcinoma , in vitro , cellular respiration , chemistry , biology , mitochondrion , enzyme , food science , botany
The effect of methylglyoxal (MG), ascorbic acid and lactaldehyde has been tested on the in vitro respiration of Ehrlich ascites carcinoma (EAC) cells and several normal and malignant human tissues. Methylglyoxal inhibited the respiration of each type of malignant cell and tissue tested, but it had practically no inhibitory effect on the respiration of any of the normal cells and tissues. Ascorbic acid exhibited a synergistic effect with MG in inhibiting the respiration of all the neoplastic cells. In the presence of lactaldehyde, a catabolite of MG, the inhibitory effect of MG on the respiration of tumor cells was significantly reduced. Lactaldehyde can exert a similar protective effect on the loss of viability and transplantability of MG‐treated EAC cells.