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Bilateral ovarian carcinoma: Cytogenetic evidence of unicentric origin
Author(s) -
Pejovic Tanja,
Heim Sverre,
Mandahl Nils,
Elmfors Bengt,
Furgyik Stefan,
Flodérus UllaMaria,
Helm GÖRan,
Willén Helena,
Mitelman Felix
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470308
Subject(s) - karyotype , ovary , ovarian carcinoma , ovarian cancer , pathology , biology , carcinoma , epithelioma , cytogenetics , cancer , medicine , chromosome , endocrinology , genetics , gene
Cytogenetic analyses were performed on the tumors from both ovaries in 15 patients with bilateral ovarian carcinoma. In 4 of them, omental implants were also examined. Abnormal karyotypes were detected in 11 cases. The baseline karyotypes in the 2 tumorous ovaries were identical in each patient, indicating that bilateral ovarian cancer develops by metastatic spreading. There was no clear‐cut evidence of differences in the clonal evolution between the tumors of the 2 ovaries, and hence the side harboring the primary tumor could never be determined. The metastatic nature of the omental implants was proved by the fact that their karyotypes were indistinguishable from those of the ovarian tumor tissue.