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Kaposi's sarcoma and non‐hodgkin's lymphoma in european aids cases. no excess risk of kaposi's sarcoma in mediterranean countries
Author(s) -
Casabona Jordi,
Melbye Mads,
Biggar Robert J.
Publication year - 1991
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910470110
Subject(s) - sarcoma , medicine , kaposi's sarcoma , lymphoma , malignancy , demography , cancer , risk factor , non hodgkin's lymphoma , disease , epidemiology , pathology , human herpesvirus , sociology
Prior to the AIDS epidemic, Kaposi's sarcoma (non‐AIDS‐KS) in Europe was mainly a disease of elderly Mediterranean men. In 1989 AIDS data from 15 European countries were collected to study proportional trends in AIDS‐related Kaposi's sarcoma (AIDS‐KS) in order to determine whether specific factors in Southern Europe might be important in the development of KS among AIDS patients. Another AIDS‐related cancer, non‐Hodgkin's lymphoma (NHL) was included as a malignancy control. Of 22,367 AIDS cases reported, 3,779 (16.9%) were KS and 741 (3.3%) were NHL. A significant, continuous fall in the percentage of AIDS‐KS was seen for both homosexual men and other members of exposure groups during the period 1981‐89 ( p ‐trend <0.000l). The proportion with AIDS‐KS decreased from 40.5% in 1983 to 26.5% in 1988 in homosexual men and from 12.2 to 3.6% in other exposure groups, respectively. No significant change was observed in the proportion of NHL cases among any of the risk groups over time, although a tendency towards a slight increase was noted for homosexual men. Comparing proportional trends of KS and NHL geographically, no significant difference was found overall, by time or by exposure group. In conclusion, a specific decline is observed over time for AIDS‐KS. However, if geographically‐restricted factors are important in the development of non‐AIDS‐KS in Europe, the same factors do not appear to affect the risk of AIDS‐KS.