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Expression of intercellular adhesion molecule‐1 (ICAM‐1) on renal‐cell cancer: Possible significance in host immune responses
Author(s) -
Tomita Yoshihiko,
Nishiyama Tsutomu,
Watanabe Hisami,
Fujiwara Michio,
Sato Shotaro
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910460609
Subject(s) - intercellular adhesion molecule 1 , cell adhesion molecule , immune system , intercellular adhesion molecule , mononuclear cell infiltration , tumor necrosis factor alpha , peripheral blood mononuclear cell , icam 1 , cancer research , infiltration (hvac) , biology , immunohistochemistry , intracellular , renal cell carcinoma , pathology , tumor infiltrating lymphocytes , cell , cell adhesion , in vitro , immunology , medicine , cd8 , microbiology and biotechnology , materials science , biochemistry , composite material
In this study we examined the expression of intercellular adhesion molecule‐1 (ICAM‐I) in 28 cases of renal‐cell cancer (RCC). We also examined ICAM‐I expression on RCC cell lines in response to cytokines. Immunohistochemistry revealed frequent expression (23 positive cases among the 28 RCCs) of ICAM‐I in RCC. The molecule was not detected on renal tubular cells as far as could be determined. Furthermore, the number of ICAM‐I‐positive cells in RCC was significantly correlated with the degree of mononuclear cell infiltration, involving mainly T lymphocytes and a smaller number of macrophages bearing the LFA‐I molecule. Expression of ICAM‐I on RCC cell lines was augmented by in vitro treatment with interferon (IFN)‐γ, tumor necrosis factor (TNF)‐α and interleukin‐I (IL‐I)β. These results suggest that the expression of ICAM‐I on RCC might be modified by cytokines produced by tumor‐infiltrating mononuclear cells, and that ICAM‐I expression on RCC might augment the host immune reaction.