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Resistance to a non‐immunogenic tumor, induced by Corynebacterium parvum or Listeria monocytogenes , is abrogated by anti‐interferonγ
Author(s) -
Keller Robert,
Keist Ruth,
Leist Thomas P.,
Van Der Meide Peter H.
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910460423
Subject(s) - listeria monocytogenes , immune system , monoclonal antibody , microbiology and biotechnology , immunotherapy , interferon , biology , inoculation , antibody , immunology , cancer research , bacteria , genetics
The complex processes that determine the outcome of the interaction of tumor and host were explored in the operationally simple and reproducible rat D‐12 ascites tumor model. Animals exhibit weak spontaneous resistance against this tumor that is not augmented by repeated inoculation, by various routes, of irradiated syngeneic D‐12 tumor cells, but considerably enhanced after local administration of heatkilled Corynebacterium parvum (CP) or Listeria monocytogenes (LM) organisms. Inoculation of conventional or monoclonal anti‐rat IFNγ antibodies into the same compartment did not affect spontaneous tumor resistance, but largely abrogated the tumor‐protective effect triggered by CP or LM. Our findings support the concept that IFNγ, produced by T cells in the course of the specific immune response raised against immunogenic micro‐organisms, is able to enhance and to maintain local tumor resistance and thus to strengthen the capacity of the host to cope with a non‐immunogenic tumor.