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Risk factors for hepatocellular carcinoma in catalonia, spain
Author(s) -
Mayans M Vall,
Calvet X.,
Bruix J.,
Bruguera M.,
Costa J.,
Estève J.,
Bosch F. X.,
Bru C.,
Rodés J.
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910460307
Subject(s) - hepatocellular carcinoma , medicine , odds ratio , hbsag , cirrhosis , hepatitis b virus , gastroenterology , confidence interval , hepatitis c virus , hepatitis b , risk factor , carcinoma , case control study , alcohol consumption , alcohol , immunology , virus , biochemistry , chemistry
The influence of hepatitis B virus infection, alcohol consumption, tobacco smoking and use of oral contraceptives on the risk of hepatocellular carcinoma (HCC) was evaluated in a hospital‐based case‐control study in Catalonia, in the Mediterranean coastal area of north‐eastern Spain. A total of 96 HCC cases (86.5% of them with associated liver cirrhosis) and 190 age‐ and sex‐matched controls were studied. The odds ratio of HCC and 95% confidence interval among hepatitis B surface antigen (HBsAg) carriers was 4.9 (1.3‐21.9). The OR was not significantly elevated in smokers, and a marginally significant increased risk was found among users of oral contraceptives based on 6 female cases. There was a significant dose‐response relationship between alcohol consumption and risk of HCC (X 2 for trend: 24.3, p < 0.001). Although hepatitis B infection was strongly associated with HCC, alcohol abuse leading to cirrhosis appears to be one of the main causes of HCC in this region.