Fusion of rous‐sarcoma‐virus‐transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site | Zendy

Green A. R. | Zendy; Poole C. J. | Zendy; Povey S. M. | Zendy; Rowe D. | Zendy; Searle S. | Zendy; Wyke J. A. | Zendy

Premium

Fusion of rous‐sarcoma‐virus‐transformed rat cells to morphologically normal human or rat cells results in transcriptional suppression of the provirus that depends on its chromosomal integration site

Author(s) -

Green A. R.,

Poole C. J.,

Povey S. M.,

Rowe D.,

Searle S.,

Wyke J. A.

Publication year - 1990

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910460213

Subject(s) - rous sarcoma virus , provirus , biology , cell fusion , clone (java method) , virus , virology , long terminal repeat , genetics , cell , microbiology and biotechnology , gene , genome

The fusion of a Rous sarcoma virus (RSV)‐transformed rat fibroblast clone to at least 2 different human cell types reproducibly produces phenotypically normal hybrids. Analysis of such hybrids reveals that proviral silence is the result of transcriptional down‐regulation, presumably by a trans ‐acting human molecule. Furthermore, this phenomenon seems to be strongly influenced by the proviral chromosomal integration site and its imposition may entail a mechanism that is required only transiently.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research