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Circulating antibodies against c‐ MYC oncogene product in sera of colorectal cancer patients
Author(s) -
BenMahrez Kamel,
Sorokine Irène,
Thierry Dominique,
Kawasumi Toshiyuki,
Ishii Sunsuke,
Salmon Remy,
Kohiyama Masamichi
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910460109
Subject(s) - antibody , colorectal cancer , western blot , oncogene , cancer , medicine , microbiology and biotechnology , polyclonal antibodies , immunology , biology , gene , biochemistry , cell cycle
We developed a Western blot assay using purified human c‐ myc protein expressed in E. coli in order to look for circulating anti‐c‐ myc antibodies in human sera. The presence of IgG antibodies against c‐ myc was observed in 25 out of 44 sera from patients with colorectal cancer diagnosed and treated at the Hǒpital Curie in Paris, compared to the sera of 46 normal donors of which only 8 samples were positive ( p = 0.001).