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Aromatic amine acetyltransferase as a marker for colorectal cancer: Environmental and demographic associations
Author(s) -
Wohlleb James C.,
Hunter Carolyn F.,
Blass Baxter,
Kadlubar Fred F.,
Chu David Z. J.,
Lang Nicholas P.
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910460107
Subject(s) - odds ratio , colorectal cancer , cruciferous vegetables , confidence interval , medicine , heterocyclic amine , cancer , environmental health , demography , oncology , carcinogen , biology , genetics , sociology
In this pilot, case‐controlled investigation of 43 colorectal and 41 control male patients, we compared associations of colorectal cancer with the aromatic amine acetyltransferase polymorphism, nutritional and demographic characteristics, medical histories, industrial and occupational histories, and exposures from home environments and personal habits. Persons with the “fast” acetylator trait were at greater risk of colorectal cancer (odds ratio: 2.48; 95% confidence interval: 1.02, 6.03). Results that differed from previous reports were positive associations of colorectal cancer with agricultural and manufacturing industries and with consumption of meats prepared by smoking, curing, and barbecueing. As expected, exercise frequency, cruciferous vegetables, and dietary fiber served as protective factors.