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Deficiency in catalase activity correlates with the appearance of tumor phenotype in human keratinocytes
Author(s) -
Rabilloud Thierry,
Asselineau Daniel,
Miquel Corinne,
Calvayrac Regis,
Darmon Michel,
Vuillaume Monique
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450529
Subject(s) - catalase , phenotype , cell culture , keratinocyte , in vitro , biology , tumor progression , cell , cancer research , microbiology and biotechnology , enzyme , immunology , gene , genetics , biochemistry
Biopsies isolated from various human stratified epitheliomas and cultures of the associated fibroblasts exhibit a break‐down in catalase activity (70 to 95%). We report here that primary human cultures of keratinocytes and various immortalized keratinocyte cell lines differ from one other in their catalase activity. Moreover, deficient catalase activity appears to be related to the intensity of tumor phenotype expression. Since catalase activity in cell lines transformed in vitro is not as weak as activity observed in cell lines isolated from tumors, catalase deficiency may follow the successive steps of tumor progression.