Premium
pp60 c‐src protein kinase activity in human gastric carcinomas
Author(s) -
Takekura Naoki,
Yasui Wataru,
Yoshida Kazuhiro,
Tsujino Tetsuhiro,
Nakayama Hirofumi,
Kameda Takashi,
Yokozaki Hiroshi,
Ishimura Yasuhiko,
Ito Hisao,
Tahara Eiichi
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450510
Subject(s) - proto oncogene tyrosine protein kinase src , kinase , carcinoma , biology , microbiology and biotechnology , carcinoma cell , cancer research , protein kinase a , chemistry , cell , biochemistry , genetics
We examined pp60 c‐src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60 c‐src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60 c‐src kinase activity in tumor tissues than in corresponding normal mucosa. However, the levels of expression ofpp60 c‐src detected by Western blotting were not always consistent with the activities of pp60 c‐src protein kinase. These findings suggest that the increase in pp60 c‐src protein kinase activity might be brought about by post‐translational changes.