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Identification of T‐cell antigens expressed by metastatic T‐cell hybridomas and lymphomas
Author(s) -
Van Hecke Dominique,
Verschueren Hendrik,
De Baetselier Patrick
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450433
Subject(s) - sialoglycoprotein , antigen , in vitro , t cell , cell , biology , immunology , cancer research , microbiology and biotechnology , pathology , immune system , antibody , medicine , biochemistry
Using the murine BW5147 tumor model system, we have identified 3 MAbs that discriminate between metastatic and non‐metastatic BW5147‐derived T‐cell hybridomas and BW5147‐unrelated T‐lymphomas. The 3 rat MAbs appear to recognize an identical membrane‐associated sialoglycoprotein with an approximate molecular weight of 95–100 kDa. We thus defined “metastatic T‐cell hybridoma” antigens (MTH‐Ags) that are also expressed on normal T‐lymphocytes. No correlation was found between the expression of the MTH Ags and in vitro invasive behavior of normal and malignant cells. Neither did we find any relationship between organ specificity of i.v. inoculated tumor cells and their MTH‐Ags expression. It thus remains unclear whether our MTH‐Ags are functionally involved in the metastatic process, or whether their expression is only incidentally related to the metastatic potential.