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Alpha 1 ‐antitrypsin and survival in pancreatic cancer
Author(s) -
Trichopoulos Dimitrios,
Tzonou Anastasia,
Kalapothaki Victoria,
Sparos Loucas,
Kremastinou Tzenny,
Skoutari Maria
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450419
Subject(s) - medicine , pancreatic cancer , pancreas , case fatality rate , cancer , gastroenterology , proportional hazards model , survival analysis , survival rate , epidemiology
The association between serum levels of alpha 1 ‐antitrypsin (a 1 AT) at the time of diagnosis and survival was studied in a group of 44 patients with confirmed pancreas cancer. All 44 patients were followed until time of death, which occurred in all cases from pancreas cancer, with a median time of 3 months and a range of 0.5 to 16 months. Cox's proportional hazards model was utilized in the analysis controlling for sex, age and tobacco smoking. Males, older patients and smokers have higher fatality rates, but none of these relations was statistically significant. By contrast, there was a statistically highly significant association of increased levels of serum a 1 AT, at the time of diagnosis of the cancer of pancreas, with shorter survival; patients with serum a 1 AT higher by 100mg/100ml had a 57% higher fatality rate. These results indicate that serum a 1 AT represents a clinically interesting prognostic factor in pancreas cancer.