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Increased levels of 5‐fluorouracil‐induced dna lesions in bloom's syndrome
Author(s) -
Lönn Ulf,
Lönn Sigrid,
Nylen Urban,
Winblad Gerard
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450321
Subject(s) - fluorouracil , bloom , bloom syndrome , dna , medicine , biology , pathology , genetics , chemotherapy , rna , gene , ecology , helicase
In Bloom's syndrome (BS) the regulation of uracil‐DNA glycosylase, an enzyme involved in the repair of DNA containing 5‐FU, is altered. 5‐FU induces higher levels of DNA fragmentation in BS cells than in non‐BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5‐FU is incorporated into DNA. When 5‐FU induces DNA fragmentation by a mechanism not involving the incorporation of drug into DNA, the levels of DNA fragmentation in BS and non‐BS cells remain similar.