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Use of monoclonal antibodies to human breast‐tumor‐associated antigens in the diagnosis of fine‐needle aspirates of breast nodules: Results of a multicenter study
Author(s) -
Natali P. G.,
Mottolese M.,
Perrone Donnorso R.,
Buffa R.,
Bussolati G.,
Coggi G.,
Corradi G.,
CosciaPorrazzi L.,
Ferretti M.,
Rondanelli E.,
Castagna M.,
Vecchione A.,
Siccardi G. A.
Publication year - 1990
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910450104
Subject(s) - monoclonal antibody , medicine , antigen , pathology , multicenter study , monoclonal , tumor associated antigen , mammary gland , antibody , breast cancer , immunology , cancer , randomized controlled trial
Fine‐needle aspiration (FNA) cytology is being increasingly employed in conjunction with physical examination and mammography in the pre‐surgical diagnosis of breast nodules. In the present study, we have submitted to multicenter validation an immunocytochemical test which employs monoclonal antibodies (MAbs) to breast‐tumor‐associated antigens (BTAA) for the diagnosis of breast cancer. The results of this analysis, which has evaluated 846 FNAs, show that the immunological test has a sensitivity of 88.62%, a specificity of 97.9% and an accuracy of 92.4%. The predictive value of a positive and a negative finding were 98.4% and 85.57% respectively. Comparison between the cytological and immunocytochemical diagnosis displayed a higher sensitivity, accuracy and predictive value of a negative result with the latter method ( p <0.01). Our findings clearly indicate that immunocytochemical methods can complement and improve the diagnostic accuracy of FNA cytology of breast nodules.