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Signal transduction by p21 ras
Author(s) -
Marshall C. J.,
Lloyd A. C.,
Morris J. D. H.,
Paterson H.,
Price B.,
Hall A.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440708
Subject(s) - signal transduction , transduction (biophysics) , medicine , biology , neuroscience , microbiology and biotechnology , biochemistry
Experiments using the physical loading of purified recombinant p21 ras proteins into quiescent normal cells to analyze how the proteins stimulate DNA synthesis and morphological transformation are reviewed. The results indicate that oncogenic p21 ras proteins rapidly activate a protein‐kinase‐C‐dependent pathway and a protein‐kinase‐C‐independent pathway. The activation of protein kinase C is absolutely required for p21 ras to stimulate DNA synthesis but is not required for morphological transformation.