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Intrinsic differences in the transplantability and outgrowth potential of DMBA‐induced rat mammary tumors
Author(s) -
Rivera Evelyn M.,
AlstonMills Brenda
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440618
Subject(s) - dmba , mammary gland , mammary carcinoma , medicine , pathology , biology , cancer research , breast cancer , cancer , carcinogenesis , carcinoma
Only a small proportion of DMBA‐induced rat mammary tumors are transplantable in cleared (gland‐free) mammary fat pads. To enhance their transplantability, several host factors were modified: age, parity, hormone levels, and tissue integrity of the fat pad. Our 2 important findings were that (1) there were individual differences between the tumors in their transplantability and potential to proliferate normal and hyperplastic outgrowths, and (2) these differences were determined by their inherent potential and not by their environment. These intrinsic differences among the tumors are consistent with the concept that properties of a given type of tumor are independently variable.