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Frequent clonal chromosomal changes in human non‐malignant tumors
Author(s) -
Teyssier J. R.,
Ferre D.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440514
Subject(s) - biology , carcinogenesis , pathology , chromosome , aneuploidy , ploidy , karyotype , cytogenetics , cancer research , cancer , genetics , gene , medicine
A cytogenetic analysis has been performed on 109 nonmalignant human solid tumors of various histological types after short‐term culture. These tumors were derived from epithelial, mesenchymal, embryonal and neurogenic tissues. The chromosome count was in the diploid range in virtually all specimens. Clonal chromosomal changes were found in 37% of tumors: 20% had numerical deviations, 12% structural rearrangements, and 5% both karyotypic alterations. Chromosome 7 was most frequently involved in 25% of abnormal specimens. Our results suggest that chromosomal changes contribute to non‐malignant tumorigenesis and that their analysis may provide information about the genetic events which shift benign tumor cells to malignant behavior.