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Bladder cancer and occupational exposure to polycyclic aromatic hydrocarbons
Author(s) -
Bonassi Stcfano,
Mfrlo Franco,
Pearce Neil,
Puntoni Riccardo
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440415
Subject(s) - bladder cancer , occupational exposure , confounding , job exposure matrix , risk factor , medicine , case control study , cancer , carcinogen , population , epidemiology , environmental health , chemistry , biochemistry
The association between occupational exposure to polycy‐clic aromatic hydrocarbons (PAH) and bladder cancer development was investigated in a population‐based case‐control study carried out in the Bormida valley, Italy. One hundred and twenty‐one male cases and 342 male controls, matched by age were collected from local hospitals. Occupational exposure to PAH and aromatic amines (AA) was evaluated by means of a job exposure matrix, constructed specifically for this study. Subjects considered as sharing a “definite exposure to PAH” showed an increased risk even after adjustment for cigarette smoking and exposure to AA (OR = 2.14, 95% CL 0.82‐5.60). No elevation in risk was found for the category “possible exposure to PAH” (OR = 1.05, 95% CL 0.45‐2.44). The findings of this study are consistent with previous studies indicating PAH as a risk factor for bladder cancer. A possible residual confounding effect due to AA impurities is discussed.