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Transplantable Marek's disease lymphomas. III. Induction of MHC‐restricted tumor immunity by lymphoblastoid cells in F 1 hosts
Author(s) -
Difronzo Nancy L.,
Schierman Louis W.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440316
Subject(s) - marek's disease , lymphoblast , immune system , biology , antigen , major histocompatibility complex , virology , immunity , immunology , immunization , virus , cell culture , genetics
F 1 chickens, which were a cross between birds of the related inbred lines G‐BI and G‐B2, were immunized with in vitro cultured virus‐non‐producer lymphoblastoid cells that were either syngeneic or allogeneic with the challenge tumor cells. The lymphoblastoid cells were derived from Marek's disease herpesvirus (MDV)‐induced transplantable tumors. Previous findings showed that such immunization of G‐BI and G‐B2 chickens prevented early mortality caused by the tumors. Lymphoblastoid cells syngeneic with the tumors were more effective than allogeneic cells, suggesting that an MHC‐restricted immune response was induced, or, alternatively, that immune elimination of allogeneic cells prevented them from initiating strong immunity to MDV‐associated tumor antigens. Immune elimination of the immunizing cells should not occur in F 1 birds heterozygous for the 2 different parental MHC haplotypes ( B 6 and B 13 ). Early mortality among F 1 chickens immunized with lymphoblastoid cells that were syngeneic with the challenge tumor cells was significantly lower than for non‐immunized control chickens or for birds immunized with lymphoblastoid cells that were allogeneic with the challenge tumor cells. Our results suggest that MDV‐induced tumor antigens may be recognized by the host as altered‐self MHC antigens.