Quantification of epidermal growth factor in human breast cyst fluids: Correlation with dehydroepiandrosterone‐sulphate and electrolyte concentrations | Zendy

Smith K. | Zendy; Miller W. R. | Zendy; Fennelly J. A. | Zendy; Matthews J. N. S. | Zendy; Scott W. N. | Zendy; Harris A. L. | Zendy

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Quantification of epidermal growth factor in human breast cyst fluids: Correlation with dehydroepiandrosterone‐sulphate and electrolyte concentrations

Author(s) -

Smith K.,

Miller W. R.,

Fennelly J. A.,

Matthews J. N. S.,

Scott W. N.,

Harris A. L.

Publication year - 1989

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910440207

Subject(s) - cyst , epidermal growth factor , endocrinology , medicine , chemistry , dehydroepiandrosterone , biology , hormone , pathology , androgen , receptor

Epidermal growth factor (EGF), dehydroepiandrosterone (DHA)‐sulphate and [Na + ] and [K + ] were assayed in 78 cyst fluids from patients with a palpable breast cyst. Epidermal growth factor was detected in all but 2 cysts, the mean value ± Sem being 506.2 ± 39.3 ng/ml, with a range of 0‐1,599 ng/ml. When the cyst fluids were sub‐divided according to their [Na + ]:[K + ] ratio, group A cyst fluids ([Na + ]:[K + ] < 3) had a significantly higher (p < 0.001) level of EGF than group B cyst fluids ([Na + ]:[K + ] > 3). Furthermore, the relationship between EGF and [Na + ] and [K + ] and between EGF and DHA‐sulphate seemed to differ between the 2 cyst types and each cyst type was therefore analyzed separately.

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