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Quantification of epidermal growth factor in human breast cyst fluids: Correlation with dehydroepiandrosterone‐sulphate and electrolyte concentrations
Author(s) -
Smith K.,
Miller W. R.,
Fennelly J. A.,
Matthews J. N. S.,
Scott W. N.,
Harris A. L.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910440207
Subject(s) - cyst , epidermal growth factor , endocrinology , medicine , chemistry , dehydroepiandrosterone , biology , hormone , pathology , androgen , receptor
Epidermal growth factor (EGF), dehydroepiandrosterone (DHA)‐sulphate and [Na + ] and [K + ] were assayed in 78 cyst fluids from patients with a palpable breast cyst. Epidermal growth factor was detected in all but 2 cysts, the mean value ± Sem being 506.2 ± 39.3 ng/ml, with a range of 0‐1,599 ng/ml. When the cyst fluids were sub‐divided according to their [Na + ]:[K + ] ratio, group A cyst fluids ([Na + ]:[K + ] < 3) had a significantly higher (p < 0.001) level of EGF than group B cyst fluids ([Na + ]:[K + ] > 3). Furthermore, the relationship between EGF and [Na + ] and [K + ] and between EGF and DHA‐sulphate seemed to differ between the 2 cyst types and each cyst type was therefore analyzed separately.