Cytogenetic study on eleven cutaneous neoplasms and two pre‐tumoral lesions from xeroderma pigmentosum patients | Zendy

Aledo Rosa | Zendy; Dutrillaux Bernard | Zendy; Lombard Martine | Zendy; Aurias Alain | Zendy

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Cytogenetic study on eleven cutaneous neoplasms and two pre‐tumoral lesions from xeroderma pigmentosum patients

Author(s) -

Aledo Rosa,

Dutrillaux Bernard,

Lombard Martine,

Aurias Alain

Publication year - 1989

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910440115

Subject(s) - xeroderma pigmentosum , pathology , chromosomal translocation , biology , melanoma , cytogenetics , basal cell , basal cell nevus syndrome , basal cell carcinoma , chromosome , cancer research , dermatology , medicine , dna , genetics , dna damage , gene

Eleven independent tumors (5 basal‐cell carcinomas, 5 squamous‐cell carcinomas and 1 malignant melanoma), 2 pre‐tumoral lesions and one common nevus, developing in the skin of 10 unrelated XP patients were cytogenetically analyzed. No specific chromosomal changes were observed. Two features were relevant, however: emergence of several independent clones and over‐involvement of telomeric and cen‐tromeric regions in the formation of chromosomal rearrangements, jumping translocations were observed in 2 squamous‐cell carcinomas involving telomeric and centromeric regions.

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