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Polyoma t‐antigen‐derived synthetic peptides induce polyoma‐virus‐specific macrophage migration inhibition
Author(s) -
Reinholdsson Git,
Ramqvist Torbjörn,
Sziget Robert,
Dalianis Tina
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430633
Subject(s) - polyoma virus , macrophage , antigen , virus , virology , biology , peptide , chemistry , immunology , microbiology and biotechnology , in vitro , biochemistry
Abstract Synthetic peptides, 2 derived from the sequence common to small, middle and large T‐antigen, and I derived from the sequence unique for middle T, activated lymphocytes from polyoma‐virus‐immunized, but not from control mice, to release the lymphokine migration inhibitory factor (MIF). In contrast, purified, bacterially grown, full‐length small T‐antigen and a middle T‐antigen mutant Py 1387T MT (lacking 37 C‐terminal amino acids) did not induce lymphokine release, although they were capable of inducing an antipolyoma TSTA response in vivo .