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Human papillomavirus infection and anal cancer
Author(s) -
Beckmann Anna Marie,
Daling Janet R.,
Sherman Karen J.,
Maden Christopher,
Miller Beth A.,
Coates Ralph J.,
Kiviat Nancy B.,
Myerson David,
Weiss Noel S.,
Hislop T. Gregory,
Beagrie Marjorie,
McDougall James K.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430615
Subject(s) - anal cancer , hpv infection , anus , pathology , cancer , population , squamous carcinoma , malignant transformation , anal carcinoma , papillomaviridae , biology , koilocyte , sex organ , carcinoma in situ , carcinoma , medicine , cervical cancer , cervical intraepithelial neoplasia , ecology , genetics , environmental health
To study the association of human papillomavirus (HPV) infection with anal cancer, we examined tissue specimens from 126 patients with malignant lesions of the anal skin or mucosa. The patients were enrolled in a population‐based, case‐control study of ano‐rectal cancer which is being conducted in the state of Washington and the Province of British Columbia. Histologic sections from formalin‐fixed, paraffinembedded tissues were tested for the presence of HPV DNA by in situ hybridization with biotin‐labelled HPV 6, 11, 16, 18 and 31 DNA probes. HPV DNA sequences were found in tumor tissues from 24 of the 126 subjects (19.0%). When only squamous neoplasms are considered, 23 of 70 subjects (32.9%) had lesions which contained detectable HPV DNA. One HPV‐positive patient had a cloacogenic carcinoma that contained regions of squamous differentiation and it was in these squamous cells that HPV DNA was localized. Of the 23 squamous lesions that harbored detectable HPV DNA, 8 contained HPV 6, 10 contained HPV 16, I contained HPV 18 and 4 contained an unclassified virus type(s). HPV DNA was found in tissues from 14 patients with carcinoma‐ in situ and 10 subjects with invasive carcinoma. These results demonstrate that some malignant tumors of the anus, in both men and women, are associated with HPV infection. We conclude that the anal squamous epithelium is another site where infection with the common genital tract HPVs may carry a risk of malignant transformation.