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High frequency of Ki‐ ras codon 12 mutations in pancreatic adenocarcinomas
Author(s) -
Grünewald Kurt,
Lyons John,
Fröhlich Anja,
Feichtinger Hans,
Weger Richard A.,
Schwab Gerhard,
Janssen Johannes W. G.,
Bartram Claus R.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430614
Subject(s) - adenocarcinoma , mutation , cancer research , biology , genetics , medicine , oncology , gene , cancer
The frequency of Ki‐ ras gene mutations was studied in 100 paraffin‐embedded sections obtained from 63 pancreatic adenocarcinomas by in vitro amplification of target sequences via polymerase chain reaction (PCR) and selective oligonucleotide hybridization. Forty‐seven (75%) of the tumors contained a Ki‐ ras mutation at codon 12. No predominant amino acid substitution or nucleotide transition at this codon was observed. Two carcinomas exhibited 2 distinct Ki‐ ras mutations. No particular correlation could be established between the incidence of Ki‐ ras mutation and clinical parameters (sex, age, survival), tumor grade or tumor stage.