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The EcoRI rflp of c‐ MOS in patients with non‐Hodgkin's lymphoma and acute lymphoblastic leukemia, compared to geriatric and non‐Geriatric controls
Author(s) -
ChenevixTrench G.,
Southall M.,
Kidson C.
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430613
Subject(s) - lymphoma , restriction fragment length polymorphism , medicine , southern blot , ecori , leukemia , locus (genetics) , allele , oncology , hodgkin lymphoma , cancer , genotype , gastroenterology , genetics , biology , gene , restriction enzyme
We have used Southern blot analysis to type individuals for the presence or absence of a rare EcoRI RFLP at the c‐ mos proto‐oncogene locus. This polymorphism has previously been reported to be associated with cancer. Ninety‐eight patients with non‐Hodgkin's lymphoma (NHL) or acute lymphoblastic leukemia (ALL) and 154 cancer‐free individuals, including 108 geriatric patients with no family history of cancer, were studied. Because 4 geriatric patients (aged 67‐94) were found to have the rare c‐ mos allele (A2), and the frequency of this A2 allele was no higher among the lymphoma/leukemia patients than among cancer‐free individuals, it is unlikely that it constitutes a marker for NHL or ALL.