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Inhibition of dmba‐induced mammary tumorigenesis by caloric restriction in rats fed high‐fat diets
Author(s) -
Klurfeld David M.,
Welch Carrie B.,
Lloyd Lisa M.,
Kritchevsky David
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430532
Subject(s) - dmba , mammary tumor , endocrinology , caloric theory , medicine , corn oil , carcinogenesis , weight gain , tumor promotion , insulin , depot , body weight , fat pad , biology , adipose tissue , cancer , breast cancer , history , archaeology
Most previous studies on the inhibiting effect of caloric restriction during promotion of DMBA‐induced mammary carcinogenesis have used low to moderate levels of dietary fat, i.e. , about 4 to 14% by weight. The current study was designed to test whether a moderate degree of caloric restriction, 25%, would inhibit tumor growth in rats fed the equivalent of 20% dietary fat which approximates human consumption in affluent countries. Rats were fed diets ad libitum that contained 5, 15 or 20% corn oil. Groups of rats were pair‐fed to the last 2 groups, but subjected to a 25% caloric restriction. These groups were fed 20 or 26.7% corn oil so that absolute fat intake in the paired groups was identical. Significant inhibition of tumor incidence, tumor weight, tumor burden, body fat deposition, and fasting serum insulin were observed in the 2 calorically restricted groups. We conclude that moderate caloric restriction is significantly more effective in inhibiting tumor growth than is the promoting effect of diets high in fat. Total body weight, body fat and serum insulin concentrations may be better correlates of risk of developing mammary tumors than is dietary fat.