Chromosomal assignment of woodchuck hepatitis virus (WHV) dna integration sites in a woodchuck hepatocellular carcinoma‐derived cell line (WH257GE10) | Zendy

Mizuno Yasutsugu | Zendy; Murakami Seishi | Zendy; Matsushita Fumiaki | Zendy; Unoura Masashi | Zendy; Kobayashi KenIchi | Zendy; Migita Shunsuke | Zendy; Hattori Nobu | Zendy; Ohno Sinsuke | Zendy

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Chromosomal assignment of woodchuck hepatitis virus (WHV) dna integration sites in a woodchuck hepatocellular carcinoma‐derived cell line (WH257GE10)

Author(s) -

Mizuno Yasutsugu,

Murakami Seishi,

Matsushita Fumiaki,

Unoura Masashi,

Kobayashi KenIchi,

Migita Shunsuke,

Hattori Nobu,

Ohno Sinsuke

Publication year - 1989

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910430419

Subject(s) - woodchuck hepatitis virus , biology , chromosome , hepatocellular carcinoma , dna , virology , hepatitis b virus , microbiology and biotechnology , virus , hepadnaviridae , genetics , gene

The chromosomal sites of woodchuck hepatitis virus (WHV) DNA integration were identified in a woodchuck hepatocellular carcinoma‐derived cell line (WH257GE10) by the in situ hybridization technique using 3 H‐labelled WHV whole genome (WHV 2) as a probe. The G‐banded chromosome spreads from WH257GE10 were identified and diagrammed schematicaiiy according to their band patterns. WHV DNA was integrated into 2 sites: 33 region of the long arm of chromosome 6 (6q33) and 31 region of the long arm of chromosome 8 (8q31). Chromosomal sites of WHV DNA integration were stable during successive passage periods analyzed in vitro .

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