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Actions of medroxyprogesterone acetate on the efficacy of cytotoxic drugs: Studies with human breast cancer cells in culture
Author(s) -
Shaikh Naeem A.,
Owen Alison M.,
Ghilchik Margaret W.,
Braunsberg Hannelore
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430319
Subject(s) - medroxyprogesterone acetate , medroxyprogesterone , cancer , medicine , cytotoxic t cell , breast cancer , oncology , mammary gland , human breast , cancer research , biology , estrogen , in vitro , genetics
Human breast cancer cells (MCF‐7) showed increased responses to methotrexate and vincristine after a 48‐hr pretreatment with medroxyprogesterone acetate. The effect of the hormone, which was detectable at concentrations of between 10 and 100nm, was independent of its growth‐inhibitory action. These findings confirm a previous clinical study and have important implications with regard to the management of advanced breast cancer.