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Immunophenotypic similarities of mediastinal clear‐cell lymphoma and sinusoidal (monocytoid) b cells
Author(s) -
Möller Peter,
MatthaeiMaurer D. Ulrike,
Hofmann Walter J.,
Dörken Bernd,
Moldenhauer Gerhard
Publication year - 1989
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910430104
Subject(s) - histogenesis , antigen , pathology , cd5 , lymphoma , b cell , biology , follicular lymphoma , neoplastic transformation , cd19 , cd20 , antibody , immunohistochemistry , immunology , medicine , cancer , carcinogenesis , genetics
Abstract Using 14 well‐defined (clustered) monoclonal antibodies (MAbs) against B‐cell restricted/associated differentiation and activation (CD) antigens and 12 mediastinal clear‐cell lymphomas (MCCL), 46 follicular‐center‐cell lymphomas (FCCL), and 20 non‐neoplastic lymph nodes—including toxoplasmic and HIV‐associated lymphadenitis—were immunohistochemically examined to determine the histogenesis of MCCL. Antigenically, MCCL was characterized as CD5 − , CD10 − , CD19 + , CD20 + , CD21 − , CD22 + , CD30 − , CD37 + , CDw40 + , and by a frequent expression of CD11c and CD23, while other antigens were inconsistently expressed. The antigenic profiles of MCCL and FCCL showed statistically significant differences in 4/14 distinct antigens. When the neoplastic cells of both tumor groups were compared with morphologically defined normal B‐cell types, the overall resemblance of their immunophenotypes was even closer between MCCL and sinusoidal (monocytoid) B cells than between FCCL and follicular‐center B cells. We conclude that MCCL is a lymphoma type distinct from FCCL, most probably representing a highly malignant neoplasm corresponding to sinusoidal B‐cell reaction.