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Immunohistochemical distribution of c‐ erb B‐2 in infiltrating and in situ breast cancer
Author(s) -
Gusterson B.A.,
Machin L.G.,
Gullick W.J.,
Gibbs N.M.,
Powles T.J.,
Price P.,
McKinna A.,
Harrison S.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420608
Subject(s) - immunohistochemistry , ductal carcinoma , in situ , pathology , breast cancer , in situ hybridization , mammary gland , carcinoma in situ , cancer , oncogene , staining , carcinoma , medicine , biology , gene expression , chemistry , gene , biochemistry , organic chemistry , cell cycle
An immunohistochemical study of c‐ erb B‐2 expression was performed on invasive and in situ breast cancer. Strong membrane staining was seen in 16% of the infiltrating ductal carcinomas and 44% of the in situ lesions. c‐ erb B‐2 was over‐expressed in ductal rather than lobular tumours. Our results indicate that a small sub‐group of breast carcinomas are associated with over‐expression of this oncogene which may define an important subgroup of in situ and infiltrating ductal carcinomas.