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Periampullary, colorectal and gastric cancer in two siblings
Author(s) -
Schlossberg Daniel,
Weber Walter,
Stoffel Urs,
Henggeler Karl,
Stocker Hans,
Foeppl Mario,
Akovbiantz Arik
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420607
Subject(s) - medicine , colorectal cancer , gastroenterology , gastric carcinoma , carcinoma , familial adenomatous polyposis , cancer , oncology
We describe a sibship affected by subsequent periampullary, colorectal and gastric carcinoma. Three of 4 siblings (2 males, 1 female) developed a periampullary carcinoma at the age of 20, and the 2 brothers subsequently had colorectal and gastric carcinoma. One of them also had familial adenomatous polyposis. There is suggestive evidence of vertical transmission of a gene predisposing to a hereditary colorectal carcinoma syndrome.