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Relationship between DNA ploidy, antigen expression and survival in renal cell carcinoma
Author(s) -
Oosterwijk E.,
Warnaar S. O.,
Zwartendijk J.,
Van Velde E. A. Der,
Fleuren G. J.,
Cornelisse C. J.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420512
Subject(s) - ploidy , renal cell carcinoma , antigen , biology , dna , carcinoma , pathology , cancer research , immunology , medicine , genetics , gene
Tumor ploidy and expression of renal differentiation antigens as recognized by a previously described series of monoclonal antibodies (MAbs) (RC2, RC3, RC4, RC38, RC69, RC154 and G250) were assessed in 48 renal‐cell carcinomas. A positive association was found between aneuploidy and development of metastases. Aneuploid tumors showed a loss of antigen expression more frequently than diploid tumors. This difference was statistically significant for antigens recognized by RC3 and RC69. Loss of RC154 reactivity was associated with increased metastatic potential. Clinical stage was the most powerful single prognostic variable but ploidy and RC3 reactivity carried additional prognostic information.