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Comparative study of plasminogen activator antigens in colonic carcinomas and adenomas
Author(s) -
Suzumiya Junji,
Hasui Yoshihiro,
Kohga Shin,
Sumiyoshi Akinobu,
Hashida Seiichi,
Ishikawa Eiji
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420426
Subject(s) - adenoma , antigen , adenocarcinoma , pathology , carcinoma , malignant transformation , epithelium , colorectal adenoma , neoplastic transformation , plasminogen activator , medicine , gastroenterology , biology , cancer , colorectal cancer , carcinogenesis , immunology
The correlation between malignant transformation and increased PA synthesis or secretion has been examined in a variety of cell lines. To study the relationship between content and composition of PAs and colorectal neoplasms, we measured u‐PA and t‐PA antigen levels in normal mucosa, tubular adenoma, adenocarcinoma in adenoma, and adenocarcinoma, using a sensitive sandwich enzyme immunoassay. This assay was very sensitive and was not hindered by the presence of serine protease inhibitors. Both adenomas and carcinomas had higher u‐PA antigen levels than normal mucosa. The u‐PA antigen level of adenomas was lower than that of carcinomas. Antigen level of t‐PA, however, was lower in both adenomas and carcinomas compared with that in normal mucosa, the values being lowest in carcinomas. Two cases of carcinoma in adenoma had PA contents similar to those of carcinomas. u‐PA antigen level of adenomas with dysplastic epithelium was higher than that of adenomas without dysplastic epithelium. Therefore, the increase of u‐PA content in adenomas could be a parameter of malignant changes in adenomas.