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Familial and sporadic breast cancer cases in Iceland: A comparison related to ABO blood groups and risk of bilateral breast cancer
Author(s) -
Tryggvadottir Laufey,
Tulinius Hrafn,
Robertson James McD.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420405
Subject(s) - abo blood group system , breast cancer , medicine , cancer , etiology , family history , family aggregation , oncology , disease , risk factor , gynecology
Abstract This study was aimed at determining whether the familial clustering often observed in breast cancer is associated with genetic factors. We compared familial and sporadic breast cancer cases with respect to ABO blood group distribution and the risk of bilateral disease, using the data from the lcelandic Cancer Registry which contains genealogical information for about 30% of the breast cancer cases diagnosed in lceland since 1911. Cases were classified as familial if at least one first‐degree relative had breast cancer. Using this criterion, we identified 184 familial cases and 572 sporadic cases. The familial cases had a 2‐fold higher prevalence of blood group B than did the sporadic cases, and the frequency of this blood group in non‐affected relatives of cases was significantly reduced. Familial cases were about 2.7 times more likely to suffer from bilateral breast cancer than were the sporadic patients. These results support the presence of a genetic factor in the etiology of familial breast cancer.