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The Danish case‐control study of cutaneous malignant melanoma. I. Importance of host factors
Author(s) -
Østerlind A.,
Tucker M. A.,
HouJensen K.,
Stone B. J.,
Engholm G.,
Jensen O. M.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420210
Subject(s) - melanoma , medicine , dermatology , danish , population , lentigo maligna , nodular melanoma , lentigo maligna melanoma , relative risk , nevus , environmental health , confidence interval , philosophy , linguistics , cancer research
The relationshop between cutaneous malignant melanoma and possible host factors was Investigated in a populationbased case‐control study from East Denmark over a 3‐year period. A total of 474 melanoma patlents and 926 population controls aged 20–79 years were interviewed. Patients with lentigo maligna melanoma were not included. The major constitutional risk factors were: number of raised naevi on the arms (RR = 5,1 for 5+ vs, none), degree of freckling (RR = 2.9 for many vs, none), and light hair colour (RR = 1.7 for blond/fair vs. dark brown/black), which were independent of one another. An apparent synergy between number of raised naevi on the arms and degree of freckling was found. Thus, persons at high risk of melanoma may be identified by a simple assessment of naevi and degree of freckling. No significent difference was found between superficial spreading melanoma and nodular melanoma with regard to the most important host factors.