Immunization against the polyoma tumor‐specific transplantation antigen (TSTA) with polyoma T‐antigens | Zendy

Ramqvist T. | Zendy; Pallas D. O. | Zendy; Deanda J. | Zendy; ÄhrlundRichter L. | Zendy; Reinholdsson G. | Zendy; Roberts T. M. | Zendy; Schaffhausen B. S. | Zendy; Dalianis T. | Zendy

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Immunization against the polyoma tumor‐specific transplantation antigen (TSTA) with polyoma T‐antigens

Author(s) -

Ramqvist T.,

Pallas D. O.,

Deanda J.,

ÄhrlundRichter L.,

Reinholdsson G.,

Roberts T. M.,

Schaffhausen B. S.,

Dalianis T.

Publication year - 1988

Publication title -

international journal of cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.475

H-Index - 234

eISSN - 1097-0215

pISSN - 0020-7136

DOI - 10.1002/ijc.2910420123

Subject(s) - antigen , biology , polyoma virus , transplantation , immunization , virology , virus , immunity , microbiology and biotechnology , immunology , immune system , medicine , surgery

The relationship between the polyoma virus tumor‐specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli . The 2 proteins induced protective immunity against polyomavirus‐induced tumors, but not against non‐polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.

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