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Immunization against the polyoma tumor‐specific transplantation antigen (TSTA) with polyoma T‐antigens
Author(s) -
Ramqvist T.,
Pallas D. O.,
Deanda J.,
ÄhrlundRichter L.,
Reinholdsson G.,
Roberts T. M.,
Schaffhausen B. S.,
Dalianis T.
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420123
Subject(s) - antigen , biology , polyoma virus , transplantation , immunization , virology , virus , immunity , microbiology and biotechnology , immunology , immune system , medicine , surgery
The relationship between the polyoma virus tumor‐specific transplantation antigen (TSTA) and 2 of the virus proteins coded from the early region of polyomavirus was investigated. Mice were immunized with small T antigen and a truncated mutant of middle T antigen, both purified from genetically engineered Escherichia coli . The 2 proteins induced protective immunity against polyomavirus‐induced tumors, but not against non‐polyoma tumors, indicating that one or more of the polyoma T antigens are directly involved in a TSTA function.