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Mast‐cell‐deficient W/W v mice exhibit A decreased rate of tumor angiogenesis
Author(s) -
Starkey Jean R.,
Crowle Patricia K.,
Taubenberger Simone
Publication year - 1988
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910420110
Subject(s) - angiogenesis , mast cell , metastasis , ratón , in vivo , lung , bone marrow , biology , cancer research , pathology , medicine , immunology , cancer , microbiology and biotechnology
The role of host mast cells in tumor‐associated angiogenesis was investigated by comparing the angiogenic response of genetically mast‐cell‐deficient W/W v mice and mast‐cell‐sufficient +/+ littermate mice to s.c. growing B16‐BL6 tumors. The angiogenic response was found to be slower and initially less intense in W/W v mice than in +/+ mice. Fewer W/W v mice than +/+ mice developed spontaneous lung metastases and W/W v mice exhibited fewer lung metastases per mouse. Bone‐marrow repair of the mast‐cell deficiency restored the angiogenic response of W/W v mice and also restored the incidence of hematogenous metastases to approach that of +/+ mice. Differences in lymphatic metastasis were not detected between W/W v and +/+ mice. These results demonstrate a role for mast cells in vivo during tumor angiogenesis, and suggest a role also for host mast cells in hematogenous metastasis.